Welcome to Bio 84: Your Genes and Your Health
Analyzing your DNA can reveal a lot about your potential health and future well being. Although knowledge of your genetic frailties may suggest a predisposition to a disease, genetics alone does not seal your fate. Most common diseases are affected by your behavior and your environment. Changing one's lifestyle can alleviate or even prevent disease. Hence, understanding genetic indicators can alert one to the importance of being vigilant about lifestyle and medical follow-ups.
In this course, we will empower you with tools to learn more about diseases, treatments and genetic tests that will help you to understand any genetic disease. The instructor will use data from his own genome to show you how you can look into your ancestry, family relationships, inherited diseases and response to drugs. You will see how knowing one's genetic profile can lead to reduced health care costs and a new approach to a confident, healthy lifestyle.
No scientific or medical background is necessary for this course. For those enrolled for a grade, the grade will be determined based on attendance (9 out of 10 lectures) and a short (4-5 page) paper due at the end of the course on a topic of interest to you and relevant to genomics and medicine. For those taking the course for Credit/No Credit, credit will depend on attendance (9 out of 10 lectures) and a one short, 1-2 page, homework assignment.
This course meets Wednesday evenings from 7:00 to 8:50 PM location to be announced upon enrollment.. You should contact Stanford Continuing Studies or the Stanford Visitors site for more information on the campus. You should access the course website (http://bio84.stanford.edu/) for all information about the course and for the course Syllabus. You may also email the instructor, Doug Brutlag, for any questions not covered by these websites.
Doug Brutlag is a Professor Emeritus of Biochemistry and Medicine (by courtesy). He teaches both undergraduate and graduate courses on Genomics and Medicine and Computational Molecular Biology at Stanford. He was a co-principal investigator on the GenBank Database and founded the first biotechnology software company. He has a B.S. with honors in Biology from the California Institute of Technology and a Ph.D. with great distinction in Biochemistry from Stanford.
Courses Taught by Doug Brutlag
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|Jan 15||Introduction: Your Genes and Your Health|
|Jan 22||Disease, Genetics and Clinical Trial Resources|
|Jan 29||The Human Genome Project|
|Feb 5||Genome Variations: SNPs and CNVs|
|Feb 12||Gene Variations Associated with Disease|
|Feb 19||What You Can Learn from Personal Genomics|
|Feb 26||The Potential of Genetic and Stem Cell Therapies to Treat Disease|
|Mar 5||MicroRNA and Epigenetic Regulation of Gene Expression||Slides|
|Mar 12||Gene Expression and Cancer Diagnostics|
|Mar 19||The Impact of Genomics on Drug Discovery, Development and Delivery|
Directions for Slide and Video links: To view videos you must first download the videos to your computer. Right click on the Video Link and ask to Save the file to your computer. This will dowload an MP4 file to your computer. Then double click or Open the downloaded file. Clicking on the Slides will automatically download a PDF file of the slides directly into your broswer. You should view the PDF of the slides while watching the video in another window so you can see the slides in higher resolution than visible in the video. Also the Web links in the Slide PDF file are all active so you can more easily follow along the lecture.
|Suggestion 1: Describe an inherited disease|
|Suggestion 2: Describe the role of a gene in an inherited disease|
|Suggestion 3: Describe a genome wide association study|
|Suggestion 4: Describe a novel stem cell or gene therapy for a disease|
|Final project ideas for students wishing a letter grade|
Students registered for credit or a letter grade must attend at least 9 of the ten class sessions and complete one of the homework assignments listed above. For those wishing credit for the course you must submit a 1-2 page paper on topics 1-4. Please click on each of the four topics above to get directions on how to do these homework assignments and what is expected. This paper must be submitted to me by email (email@example.com) as an attachement (any format is ok, Word, PDF, Google Doc, HTML, RTF etc.). This homework assignment must be sent to me by the last day of class or earlier.
If you miss a class session, you may get credit for that session by watching the video link for that class above and sending me an email (firstname.lastname@example.org) with a question on the material presented in the lecture. Upon receipt of the question I will 1) answer your question and 2) give you credit for attendance at the class.
For those wishing a letter grade, you must submit a 4-5 page final paper either on one of the four propsed topics above or on a topic of your own choice concerning genomics and health. If you want to write on a topic of your own choice, you must submit that topic to me via email for my approval. For instance you may wish to write about ethical issues of genetic selection, insurability, genetic discrimination etc. However you must get my approval for your topic before you write your paper. Again you must submit the paper to my via email (email@example.com) with a message by the date of the last lecture in the course or earlier.
To summarize, those wishing credit or a letter grade in the course must:
Attend nine (9) out of ten (10) classes. If you miss a class you may get credit for that class by watching the online video of that session and sending me an email message (firstname.lastname@example.org) with a question about the material presented in the lecture.
For a letter grade, write a four (4) to five (5) page paper which is due the last day of class or earlier..
For credit, write a one (1) to two (2) page paper on one the four (4) topics listed in the course website. Again, the paper is due the last day of class or earlier.
This reference book is not required for the course but it provides an excellent introduction to basic genetics and genomics used in both medicine and research. It also goes much deeper into the technical subjects than we will in the course so it can serve as a reference guide for those wanting a deeper and more technical understanding of the material.
This book discusses the power and impact of personal genomics and proteomics from the viewpoint of a physician and a founder of a personal genomics company, Navigenics. It is written for the layman and has appeared on the New York Times best seller list.
Another, much shorter and free text is the NCBIGenetics Home Reference Handbook that describes just the essentials and you can download the handbook at this location:
** Web Page Last Updated September 12, 2013 **